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The activated SREBP-2 enters the nucleus and initiates the transcription of its target genes

This effect may be further enhanced in a synergistic manner by probiotics through the reduction of NETs while exhibiting antioxidative properties that lower ROS production and cellular cytotoxicity (92)

Studies have observed the normalization of T-cell mitochondrial metabolism (including mitochondrial oxidative stress and redox balance) in SLE patients with metformin treatment (164166)

Treatment protocols typically range from several weeks to a few months, depending on the severity and type of condition being addressed